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AutoGen is a framework that enables the development of Next-Gen Large Language Model (LLM) applications using multiple agents that can converse with each other to solve tasks. It offers a high-level abstraction called the multi-agent conversation framework, which simplifies the building of LLM workflows. This framework allows for the easy creation of diverse applications by providing a collection of working systems that span a wide range of applications across various domains and complexities. One of the key features of AutoGen is its support for enhanced LLM inference and optimization. It provides enhanced LLM inference APIs, which can be used to improve the performance of LLM models and reduce costs. These APIs offer functionalities like caching, error handling, multi-config inference, and templating. AutoGen also supports customizable and conversable agents, which can be tailored to meet the specific needs of an application. These agents can communicate with each other to solve tasks, allowing for more complex and sophisticated applications than would be possible with a single LLM. Additionally, AutoGen seamlessly allows human participation, enabling humans to provide input and feedback to the agents as needed. AutoGen is powered by collaborative research studies from Microsoft, Penn State University, and the University of Washington. It is available as an open-source project on GitHub and provides detailed documentation, code examples, and a Discord community for support and collaboration.